Kedu ihe bụ QuickMice™?
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QuickMice ™ na-ezo aka na ụmụ oke mepụtaraTurboMice ™teknụzụ, gụnyere ma ụmụ oke mmadụ na ụmụ oke ndị ọzọ na-edezi mkpụrụ ndụ ihe nketa oge niile, dị ka Knocked-In (KI), Knocked-Out (KO), na Conditional Knocked-out (CKO).Ọzọkwa, naTurboMice ™Teknụzụ, ọrụ QuickMice ™ anyị na-asọmpi nke ukwuu nwere ike ịnye ụmụ oke ndị edezigharịrị mkpụrụ ndụ ogologo oge, ụmụ oke nwere mkpụrụ ndụ ọtụtụ mpaghara, ụmụ oke mmepụta ogbe, oke dị oke ọnụ ahịa, wdg.
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Ngwa ngwa ngwa homozygous òké QuickMice™
A na-ekwu na cell bụ homozygous maka otu mkpụrụ ndụ ihe nketa mgbe ụdị alleles nke mkpụrụ ndụ ihe nketa dị na chromosomes abụọ ahụ.
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Ndezigharị òké mmadụ nke QuickMice™ ngwa ngwa deziri
Ụdị òké ndị mmadụ mere nwere ọtụtụ ngwa na ngalaba nyocha nke AIDS, ọrịa cancer, ọrịa na-efe efe, na ọrịa ọbara.
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QuickMice™ ngwa ngwa KI nhazi nhazi
Knock-in (KI) bụ usoro na-eji nchikota nke mkpụrụ ndụ ihe nketa ga-ebufe mkpụrụ ndụ na-arụ ọrụ exogenous n'ime usoro ihe jikọrọ ya na cell na genome, wee nweta nkwupụta nke ọma na sel mgbe ejikọtachara mkpụrụ ndụ ihe nketa.
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QuickMice™ ngwa ngwa CKO òké nhazi
Conditional Knock-out (CKO) bụ nka na-ahụ maka mkpụrụ ndụ ihe nketa kpọmkwem nke e nwetara site n'usoro nchikota mpaghara.
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Ndezigharị mkpụrụ ndụ ọtụtụ mpaghara QuickMice™
Site n'itinyeTurboMice™teknụzụ, anyị nwere ike nyochaa mkpụrụ ndụ nwa embrayo ozugbo ka emechara mkpụrụ ndụ ihe nketa n'ime ụbọchị 3-5, wee wuo cell tetraploid, wee nweta ụmụ oke nwere mkpụrụ ndụ ihe nketa nke nwere ọtụtụ ebe n'ime ọnwa 3-5 ka nne ụmụ oke gachara, nke nwere ike ịchekwa otu afọ. maka ndị ahịa anyị.
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QuickMice™ ogologo mkpirisi mkpịsị aka deziri òké
TurboMice™nkà na ụzụ na-enyere aka idezi mkpụrụ ndụ ihe nketa ziri ezi nke iberibe ihe karịrị 20kb, si otú ahụ na-eme ka mmepụta ngwa ngwa nke ụdị mgbagwoju anya dị ka humanization, ọnọdụ knockout (CKO), na nnukwu mpempe akwụkwọ ịkụ aka (KI).
Usoro ọrụ
